Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema
Identifieur interne : 003904 ( Main/Exploration ); précédent : 003903; suivant : 003905Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema
Auteurs : Leonid L. Nikitenko [Royaume-Uni] ; Tatsuo Shimosawa [Japon] ; Stephen Henderson [Royaume-Uni] ; Taija M Kinen [Royaume-Uni] ; Hiromi Shimosawa [Japon] ; Uzma Qureshi [Royaume-Uni] ; R Barbara Pedley [Royaume-Uni] ; Margaret C P. Rees [Royaume-Uni] ; Toshiro Fujita [Japon] ; Chris Boshoff [Royaume-Uni]Source :
- The Journal of Investigative Dermatology [ 0022-202X ] ; 2013.
Descripteurs français
- KwdFr :
- Adrénomédulline (génétique), Animaux, Cellules cultivées, Endothélium lymphatique (métabolisme), Endothélium vasculaire (métabolisme), Facteurs de risque, Haploinsuffisance (génétique), Humains, Hétérozygote, Lymphoedème (génétique), Mutation (génétique), Phénotype, Protéine apparentée au récepteur de la calcitonine (métabolisme), Prédisposition génétique à une maladie (génétique), Souches mutantes de souris, Souris, Souris de lignée C57BL, Techniques de knock-in de gènes.
- MESH :
- génétique : Adrénomédulline, Haploinsuffisance, Lymphoedème, Mutation, Prédisposition génétique à une maladie.
- métabolisme : Endothélium lymphatique, Endothélium vasculaire, Protéine apparentée au récepteur de la calcitonine.
- Animaux, Cellules cultivées, Facteurs de risque, Humains, Hétérozygote, Phénotype, Souches mutantes de souris, Souris, Souris de lignée C57BL, Techniques de knock-in de gènes.
English descriptors
- KwdEn :
- Adrenomedullin (genetics), Animals, Calcitonin Receptor-Like Protein (metabolism), Cells, Cultured, Endothelium, Lymphatic (metabolism), Endothelium, Vascular (metabolism), Gene Knock-In Techniques, Genetic Predisposition to Disease (genetics), Haploinsufficiency (genetics), Heterozygote, Humans, Lymphedema (genetics), Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Mutation (genetics), Phenotype, Risk Factors.
- MESH :
- chemical , genetics : Adrenomedullin.
- chemical , metabolism : Calcitonin Receptor-Like Protein.
- genetics : Genetic Predisposition to Disease, Haploinsufficiency, Lymphedema, Mutation.
- metabolism : Endothelium, Lymphatic, Endothelium, Vascular.
- Animals, Cells, Cultured, Gene Knock-In Techniques, Heterozygote, Humans, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Phenotype, Risk Factors.
Abstract
Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the
Url:
DOI: 10.1038/jid.2013.47
PubMed: 23364478
PubMed Central: 3682392
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000096
- to stream Pmc, to step Curation: 000096
- to stream Pmc, to step Checkpoint: 002520
- to stream PubMed, to step Corpus: 001D27
- to stream PubMed, to step Curation: 001D27
- to stream PubMed, to step Checkpoint: 001D27
- to stream Ncbi, to step Merge: 005566
- to stream Ncbi, to step Curation: 005566
- to stream Ncbi, to step Checkpoint: 005566
- to stream Main, to step Merge: 003912
- to stream Main, to step Curation: 003904
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema</title><author><name sortKey="Nikitenko, Leonid L" sort="Nikitenko, Leonid L" uniqKey="Nikitenko L" first="Leonid L" last="Nikitenko">Leonid L. Nikitenko</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Keble College</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Linacre College</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosawa, Tatsuo" sort="Shimosawa, Tatsuo" uniqKey="Shimosawa T" first="Tatsuo" last="Shimosawa">Tatsuo Shimosawa</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Stephen" sort="Henderson, Stephen" uniqKey="Henderson S" first="Stephen" last="Henderson">Stephen Henderson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Cancer Research UK London Research Institute</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosawa, Hiromi" sort="Shimosawa, Hiromi" uniqKey="Shimosawa H" first="Hiromi" last="Shimosawa">Hiromi Shimosawa</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qureshi, Uzma" sort="Qureshi, Uzma" uniqKey="Qureshi U" first="Uzma" last="Qureshi">Uzma Qureshi</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Tumour Biology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pedley, R Barbara" sort="Pedley, R Barbara" uniqKey="Pedley R" first="R Barbara" last="Pedley">R Barbara Pedley</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Tumour Biology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rees, Margaret C P" sort="Rees, Margaret C P" uniqKey="Rees M" first="Margaret C P" last="Rees">Margaret C P. Rees</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Nuffield Department of Obstetrics and Gynaecology, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fujita, Toshiro" sort="Fujita, Toshiro" uniqKey="Fujita T" first="Toshiro" last="Fujita">Toshiro Fujita</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Research Centre for Advanced Science and Technology, Department of Clinical Epigenetics, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23364478</idno><idno type="pmc">3682392</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682392</idno><idno type="RBID">PMC:3682392</idno><idno type="doi">10.1038/jid.2013.47</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000096</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000096</idno><idno type="wicri:Area/Pmc/Curation">000096</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000096</idno><idno type="wicri:Area/Pmc/Checkpoint">002520</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002520</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001D27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D27</idno><idno type="wicri:Area/PubMed/Curation">001D27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D27</idno><idno type="wicri:Area/PubMed/Checkpoint">001D27</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D27</idno><idno type="wicri:Area/Ncbi/Merge">005566</idno><idno type="wicri:Area/Ncbi/Curation">005566</idno><idno type="wicri:Area/Ncbi/Checkpoint">005566</idno><idno type="wicri:doubleKey">0022-202X:2013:Nikitenko L:adrenomedullin:haploinsufficiency:predisposes</idno><idno type="wicri:Area/Main/Merge">003912</idno><idno type="wicri:Area/Main/Curation">003904</idno><idno type="wicri:Area/Main/Exploration">003904</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema</title><author><name sortKey="Nikitenko, Leonid L" sort="Nikitenko, Leonid L" uniqKey="Nikitenko L" first="Leonid L" last="Nikitenko">Leonid L. Nikitenko</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Keble College</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Linacre College</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosawa, Tatsuo" sort="Shimosawa, Tatsuo" uniqKey="Shimosawa T" first="Tatsuo" last="Shimosawa">Tatsuo Shimosawa</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Stephen" sort="Henderson, Stephen" uniqKey="Henderson S" first="Stephen" last="Henderson">Stephen Henderson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Cancer Research UK London Research Institute</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shimosawa, Hiromi" sort="Shimosawa, Hiromi" uniqKey="Shimosawa H" first="Hiromi" last="Shimosawa">Hiromi Shimosawa</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical Laboratory, Faculty of Medicine, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qureshi, Uzma" sort="Qureshi, Uzma" uniqKey="Qureshi U" first="Uzma" last="Qureshi">Uzma Qureshi</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Tumour Biology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pedley, R Barbara" sort="Pedley, R Barbara" uniqKey="Pedley R" first="R Barbara" last="Pedley">R Barbara Pedley</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Tumour Biology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rees, Margaret C P" sort="Rees, Margaret C P" uniqKey="Rees M" first="Margaret C P" last="Rees">Margaret C P. Rees</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Nuffield Department of Obstetrics and Gynaecology, University of Oxford</institution>, Oxford,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fujita, Toshiro" sort="Fujita, Toshiro" uniqKey="Fujita T" first="Toshiro" last="Fujita">Toshiro Fujita</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Research Centre for Advanced Science and Technology, Department of Clinical Epigenetics, The University of Tokyo</institution>, Tokyo,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Cancer Research UK Viral Oncology Group, UCL Cancer Institute, University College London</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Journal of Investigative Dermatology</title><idno type="ISSN">0022-202X</idno><idno type="eISSN">1523-1747</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenomedullin (genetics)</term><term>Animals</term><term>Calcitonin Receptor-Like Protein (metabolism)</term><term>Cells, Cultured</term><term>Endothelium, Lymphatic (metabolism)</term><term>Endothelium, Vascular (metabolism)</term><term>Gene Knock-In Techniques</term><term>Genetic Predisposition to Disease (genetics)</term><term>Haploinsufficiency (genetics)</term><term>Heterozygote</term><term>Humans</term><term>Lymphedema (genetics)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Mutant Strains</term><term>Mutation (genetics)</term><term>Phenotype</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adrénomédulline (génétique)</term><term>Animaux</term><term>Cellules cultivées</term><term>Endothélium lymphatique (métabolisme)</term><term>Endothélium vasculaire (métabolisme)</term><term>Facteurs de risque</term><term>Haploinsuffisance (génétique)</term><term>Humains</term><term>Hétérozygote</term><term>Lymphoedème (génétique)</term><term>Mutation (génétique)</term><term>Phénotype</term><term>Protéine apparentée au récepteur de la calcitonine (métabolisme)</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Souches mutantes de souris</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Techniques de knock-in de gènes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adrenomedullin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcitonin Receptor-Like Protein</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Haploinsufficiency</term><term>Lymphedema</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adrénomédulline</term><term>Haploinsuffisance</term><term>Lymphoedème</term><term>Mutation</term><term>Prédisposition génétique à une maladie</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Endothelium, Vascular</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium lymphatique</term><term>Endothélium vasculaire</term><term>Protéine apparentée au récepteur de la calcitonine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Gene Knock-In Techniques</term><term>Heterozygote</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Mutant Strains</term><term>Phenotype</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Facteurs de risque</term><term>Humains</term><term>Hétérozygote</term><term>Phénotype</term><term>Souches mutantes de souris</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Techniques de knock-in de gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Secondary lymphedema is a debilitating condition, and genetic factors predisposing to its development remain largely unknown. Adrenomedullin (AM) is peptide encoded, together with proadrenomedullin N-terminal peptide (PAMP), by the <italic>Adm</italic> gene (adrenomedullin gene). AM and its putative receptor calcitonin receptor–like receptor (CLR) are implicated in angiogenesis and lymphangiogenesis during embryogenesis and wound healing, suggesting their possible involvement in secondary lymphedema. To investigate whether AM deficiency predisposes to secondary lymphedema, we used heterozygous adult mice with <italic>Adm</italic> gene-knockin stop mutation, which selectively abrogated AM, but preserved PAMP, expression (<italic>Adm</italic><sup><italic>AM+/Δ</italic></sup> animals). After hind limb skin incision, <italic>Adm</italic> messenger RNA expression was upregulated in wounded tissue of both <italic>Adm</italic><sup><italic>AM+/+</italic></sup> and <italic>Adm</italic><sup><italic>AM+/Δ</italic></sup> mice. However, only <italic>Adm</italic><sup><italic>AM+/Δ</italic></sup> animals developed limb swelling and histopathological lymphedematous changes, including epidermal thickening, elevated collagen fiber density, and increased microvessel diameter. Secondary lymphedema was prevented when circulating AM levels in <italic>Adm</italic><sup><italic>AM+/Δ</italic></sup> mice were restored by systemic peptide delivery. In human skin, CLR was expressed in tissue components affected by lymphedema, including epidermis, lymphatics, and blood vessels. Our study identified a previously unrecognized role for endogenous AM as a key factor in secondary lymphedema pathogenesis and provided experimental <italic>in vivo</italic> evidence of an underlying germ-line genetic predisposition to developing this disorder.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Baluk, P" uniqKey="Baluk P">P Baluk</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Ator, E" uniqKey="Ator E">E Ator</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bazigou, E" uniqKey="Bazigou E">E Bazigou</name></author><author><name sortKey="Lyons, Ot" uniqKey="Lyons O">OT Lyons</name></author><author><name sortKey="Smith, A" uniqKey="Smith A">A Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brain, Sd" uniqKey="Brain S">SD Brain</name></author><author><name sortKey="Grant, Ad" uniqKey="Grant A">AD Grant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caron, Km" uniqKey="Caron K">KM Caron</name></author><author><name sortKey="Smithies, O" uniqKey="Smithies O">O Smithies</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Somanath, Pr" uniqKey="Somanath P">PR Somanath</name></author><author><name sortKey="Razorenova, O" uniqKey="Razorenova O">O Razorenova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehret, Gb" uniqKey="Ehret G">GB Ehret</name></author><author><name sortKey="Munroe, Pb" uniqKey="Munroe P">PB Munroe</name></author><author><name sortKey="Rice, Km" uniqKey="Rice K">KM Rice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finegold, Dn" uniqKey="Finegold D">DN Finegold</name></author><author><name sortKey="Baty, Cj" uniqKey="Baty C">CJ Baty</name></author><author><name sortKey="Knickelbein, Kz" uniqKey="Knickelbein K">KZ Knickelbein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finegold, Dn" uniqKey="Finegold D">DN Finegold</name></author><author><name sortKey="Schacht, V" uniqKey="Schacht V">V Schacht</name></author><author><name sortKey="Kimak, Ma" uniqKey="Kimak M">MA Kimak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fritz Six, Kl" uniqKey="Fritz Six K">KL Fritz-Six</name></author><author><name sortKey="Dunworth, Wp" uniqKey="Dunworth W">WP Dunworth</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harada, K" uniqKey="Harada K">K Harada</name></author><author><name sortKey="Yamahara, K" uniqKey="Yamahara K">K Yamahara</name></author><author><name sortKey="Ohnishi, S" uniqKey="Ohnishi S">S Ohnishi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hippenstiel, S" uniqKey="Hippenstiel S">S Hippenstiel</name></author><author><name sortKey="Witzenrath, M" uniqKey="Witzenrath M">M Witzenrath</name></author><author><name sortKey="Schmeck, B" uniqKey="Schmeck B">B Schmeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichikawa Shindo, Y" uniqKey="Ichikawa Shindo Y">Y Ichikawa-Shindo</name></author><author><name sortKey="Sakurai, T" uniqKey="Sakurai T">T Sakurai</name></author><author><name sortKey="Kamiyoshi, A" uniqKey="Kamiyoshi A">A Kamiyoshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, D" uniqKey="Jin D">D Jin</name></author><author><name sortKey="Harada, K" uniqKey="Harada K">K Harada</name></author><author><name sortKey="Ohnishi, S" uniqKey="Ohnishi S">S Ohnishi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kahn, Ml" uniqKey="Kahn M">ML Kahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kajiya, K" uniqKey="Kajiya K">K Kajiya</name></author><author><name sortKey="Hirakawa, S" uniqKey="Hirakawa S">S Hirakawa</name></author><author><name sortKey="Ma, B" uniqKey="Ma B">B Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kajiya, K" uniqKey="Kajiya K">K Kajiya</name></author><author><name sortKey="Sawane, M" uniqKey="Sawane M">M Sawane</name></author><author><name sortKey="Huggenberger, R" uniqKey="Huggenberger R">R Huggenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanter, Ma" uniqKey="Kanter M">MA Kanter</name></author><author><name sortKey="Slavin, Sa" uniqKey="Slavin S">SA Slavin</name></author><author><name sortKey="Kaplan, W" uniqKey="Kaplan W">W Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawai, J" uniqKey="Kawai J">J Kawai</name></author><author><name sortKey="Ando, K" uniqKey="Ando K">K Ando</name></author><author><name sortKey="Tojo, A" uniqKey="Tojo A">A Tojo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitamura, K" uniqKey="Kitamura K">K Kitamura</name></author><author><name sortKey="Kangawa, K" uniqKey="Kangawa K">K Kangawa</name></author><author><name sortKey="Kawamoto, M" uniqKey="Kawamoto M">M Kawamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitamura, K" uniqKey="Kitamura K">K Kitamura</name></author><author><name sortKey="Sakata, J" uniqKey="Sakata J">J Sakata</name></author><author><name sortKey="Kangawa, K" uniqKey="Kangawa K">K Kangawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, A" uniqKey="Kuhn A">A Kuhn</name></author><author><name sortKey="Brachtendorf, G" uniqKey="Brachtendorf G">G Brachtendorf</name></author><author><name sortKey="Kurth, F" uniqKey="Kurth F">F Kurth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maybin, Ja" uniqKey="Maybin J">JA Maybin</name></author><author><name sortKey="Battersby, S" uniqKey="Battersby S">S Battersby</name></author><author><name sortKey="Hirani, N" uniqKey="Hirani N">N Hirani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagaya, N" uniqKey="Nagaya N">N Nagaya</name></author><author><name sortKey="Kyotani, S" uniqKey="Kyotani S">S Kyotani</name></author><author><name sortKey="Uematsu, M" uniqKey="Uematsu M">M Uematsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name></author><author><name sortKey="Radhakrishnan, K" uniqKey="Radhakrishnan K">K Radhakrishnan</name></author><author><name sortKey="Wong, Ym" uniqKey="Wong Y">YM Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Blucher, N" uniqKey="Blucher N">N Blucher</name></author><author><name sortKey="Fox, Sb" uniqKey="Fox S">SB Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Cross, T" uniqKey="Cross T">T Cross</name></author><author><name sortKey="Campo, L" uniqKey="Campo L">L Campo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Fox, Sb" uniqKey="Fox S">SB Fox</name></author><author><name sortKey="Kehoe, S" uniqKey="Kehoe S">S Kehoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Smith, Dm" uniqKey="Smith D">DM Smith</name></author><author><name sortKey="Bicknell, R" uniqKey="Bicknell R">R Bicknell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Smith, Dm" uniqKey="Smith D">DM Smith</name></author><author><name sortKey="Hague, S" uniqKey="Hague S">S Hague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostergaard, P" uniqKey="Ostergaard P">P Ostergaard</name></author><author><name sortKey="Simpson, Ma" uniqKey="Simpson M">MA Simpson</name></author><author><name sortKey="Connell, Fc" uniqKey="Connell F">FC Connell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poyner, Dr" uniqKey="Poyner D">DR Poyner</name></author><author><name sortKey="Sexton, Pm" uniqKey="Sexton P">PM Sexton</name></author><author><name sortKey="Marshall, I" uniqKey="Marshall I">I Marshall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rutkowski, Jm" uniqKey="Rutkowski J">JM Rutkowski</name></author><author><name sortKey="Markhus, Ce" uniqKey="Markhus C">CE Markhus</name></author><author><name sortKey="Gyenge, Cc" uniqKey="Gyenge C">CC Gyenge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimosawa, T" uniqKey="Shimosawa T">T Shimosawa</name></author><author><name sortKey="Ogihara, T" uniqKey="Ogihara T">T Ogihara</name></author><author><name sortKey="Matsui, H" uniqKey="Matsui H">H Matsui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimosawa, T" uniqKey="Shimosawa T">T Shimosawa</name></author><author><name sortKey="Shibagaki, Y" uniqKey="Shibagaki Y">Y Shibagaki</name></author><author><name sortKey="Ishibashi, K" uniqKey="Ishibashi K">K Ishibashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, Ws" uniqKey="Shin W">WS Shin</name></author><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shindo, T" uniqKey="Shindo T">T Shindo</name></author><author><name sortKey="Kurihara, Y" uniqKey="Kurihara Y">Y Kurihara</name></author><author><name sortKey="Nishimatsu, H" uniqKey="Nishimatsu H">H Nishimatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanton, Aw" uniqKey="Stanton A">AW Stanton</name></author><author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name></author><author><name sortKey="Bennett Britton, Tm" uniqKey="Bennett Britton T">TM Bennett Britton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanton, Aw" uniqKey="Stanton A">AW Stanton</name></author><author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name></author><author><name sortKey="Mellor, Rh" uniqKey="Mellor R">RH Mellor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tabibiazar, R" uniqKey="Tabibiazar R">R Tabibiazar</name></author><author><name sortKey="Cheung, L" uniqKey="Cheung L">L Cheung</name></author><author><name sortKey="Han, J" uniqKey="Han J">J Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Saaristo, A" uniqKey="Saaristo A">A Saaristo</name></author><author><name sortKey="Holopainen, T" uniqKey="Holopainen T">T Holopainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tokunaga, N" uniqKey="Tokunaga N">N Tokunaga</name></author><author><name sortKey="Nagaya, N" uniqKey="Nagaya N">N Nagaya</name></author><author><name sortKey="Shirai, M" uniqKey="Shirai M">M Shirai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vart, Rj" uniqKey="Vart R">RJ Vart</name></author><author><name sortKey="Nikitenko, Ll" uniqKey="Nikitenko L">LL Nikitenko</name></author><author><name sortKey="Lagos, D" uniqKey="Lagos D">D Lagos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, Sf" uniqKey="Wilson S">SF Wilson</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name></author><author><name sortKey="Valme, Al" uniqKey="Valme A">AL Valme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name></author><author><name sortKey="Zhuo, S" uniqKey="Zhuo S">S Zhuo</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Nikitenko, Leonid L" sort="Nikitenko, Leonid L" uniqKey="Nikitenko L" first="Leonid L" last="Nikitenko">Leonid L. Nikitenko</name></noRegion><name sortKey="Boshoff, Chris" sort="Boshoff, Chris" uniqKey="Boshoff C" first="Chris" last="Boshoff">Chris Boshoff</name><name sortKey="Henderson, Stephen" sort="Henderson, Stephen" uniqKey="Henderson S" first="Stephen" last="Henderson">Stephen Henderson</name><name sortKey="M Kinen, Taija" sort="M Kinen, Taija" uniqKey="M Kinen T" first="Taija" last="M Kinen">Taija M Kinen</name><name sortKey="Nikitenko, Leonid L" sort="Nikitenko, Leonid L" uniqKey="Nikitenko L" first="Leonid L" last="Nikitenko">Leonid L. Nikitenko</name><name sortKey="Nikitenko, Leonid L" sort="Nikitenko, Leonid L" uniqKey="Nikitenko L" first="Leonid L" last="Nikitenko">Leonid L. Nikitenko</name><name sortKey="Pedley, R Barbara" sort="Pedley, R Barbara" uniqKey="Pedley R" first="R Barbara" last="Pedley">R Barbara Pedley</name><name sortKey="Qureshi, Uzma" sort="Qureshi, Uzma" uniqKey="Qureshi U" first="Uzma" last="Qureshi">Uzma Qureshi</name><name sortKey="Rees, Margaret C P" sort="Rees, Margaret C P" uniqKey="Rees M" first="Margaret C P" last="Rees">Margaret C P. Rees</name></country><country name="Japon"><noRegion><name sortKey="Shimosawa, Tatsuo" sort="Shimosawa, Tatsuo" uniqKey="Shimosawa T" first="Tatsuo" last="Shimosawa">Tatsuo Shimosawa</name></noRegion><name sortKey="Fujita, Toshiro" sort="Fujita, Toshiro" uniqKey="Fujita T" first="Toshiro" last="Fujita">Toshiro Fujita</name><name sortKey="Shimosawa, Hiromi" sort="Shimosawa, Hiromi" uniqKey="Shimosawa H" first="Hiromi" last="Shimosawa">Hiromi Shimosawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003904 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003904 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3682392
|texte= Adrenomedullin Haploinsufficiency Predisposes to Secondary Lymphedema
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23364478" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |